Preimplantation Genetic Testing for Aneuploidy, PGT-A

The purpose of the Preimplantation Genetic Testing for Aneuploidy, PGT-A/niPGT-A is to detect whether the number or the structure of chromosome is normal. Current research shows the main influence factor of repeated IVF failure, old age, habitual abortion or unknown reason infertility is the number or structure of chromosome abnormal lead the embryo can’t implant and continue develop.

Therefore, the 23 pairs of chromosome can be detected by PGT-A/niPGT-A, which can detect the abnormal chromosome number, the
chromosome segment deletion, segment duplication and other structure abnormalities. Screening out the abnormal chromosome embryos can reduce the number of embryo transfer, reduce the chance of multiple births and the chance of abortion or the fetal chromosomal abnormalities due to chromosomal abnormalities of embryo.

Suitable people of PGT-A/niPGT-A

1. Habitual abortion ( > 2 times)
2. People who have the history of chromosomal abnormalities.
3. Repeated IVF failure.
4. People who want to avoid the fetal chromosomal abnormalities.
5. Unknown reason infertility

The risks of PGT-A/niPGT-A

1. Although the accuracy of the test is as high as 92.5% or more, due to the limitation of current science technology, the detection of little segment gene dosage changes of single gene disease, chromosomal rearrangement, chromosomal inversions, balanced translocations, uniparental disomy (UPD), polyploidy, haploidy and mosaic chromosome are not included in the scope of the test.
2. For the test, DNA amplification must be performed on embryo biopsy or embryo culture medium. The success rate of amplification step is 80~85%, which means that there is about 10~15% chance of failure of amplification and the test can’t be performed.
3. There is a possibility that all the embryos are abnormal, so that no normal embryo can be transferred. But the inspections fee must still be paid.
4. Transferring the normal embryos after the PGT-A do not guarantee that the embryos can continue develop or implanted smoothly.
5. Due to the wide range of diseases and the scientific limitation of any examination, the test cannot show all possible conditions. Therefore, getting pregnant after PGT-A, chorionic villus sampling (CVS), amniocentesis, NIPT is still recommended if necessary. In order to rule out chromosomal disorders.

Case studies

One of the husband and the wife has a chromosomal abnormality (Roche’s translocation) and repeated IVF failure. By transferring a normal embryo screened by PGT-A, successfully born a baby!

▲ Because One of the husband and the wife has Roche’s translocation, the embryo has a high probability of unbalanced translocation and this embryo is haploid on chromosome 13.

▲ By transferring a normal embryo screened by PGT-A, successfully born a baby!